Cell rejuvenation therapy safely reverses aging in mice

Imagine living to be 200 or more, and healthy as a teenager the who time. 

A-lot-Longer Healthier Living Could be right around the corner.

“We are elated that we can use this approach across the life span to slow down aging in normal animals. The technique is both safe and effective in mice,” says Juan Carlos Izpisua Belmonte, co-corresponding author and a professor in Salk’s Gene Expression Laboratory.

Do I have your attention?

Here is where you can skip ahead to reading the article in Science Daily:

Salk Institute. “Cellular rejuvenation therapy safely reverses signs of aging in mice: Researchers treated mice with anti-aging regimen beginning in middle age and found no increase in cancer or other health problems later on.” ScienceDaily. ScienceDaily, 7 March 2022. <www.sciencedaily.com/releases/2022/03/220307113027.htm>.

It Keeps Getting Better

Age comes with ailments, including brittle bones and weaker muscles to increased risks of cardiovascular disease and cancer, and neurological degradation. Now, scientists at the Salk Institute, in collaboration with Genentech, a member of the Roche group, have shown that they can safely and effectively reverse the aging process in middle-aged and elderly mice by partially resetting their cells to more youthful states. The side effects of trying to keep cells younger could be increased neural capacity, meaning age-related dementia that affects millions of people may finally have an effective treatment.

Today’s science couldn’t be more exciting and you couldn’t find a better time in history to live and then this comes along. The news is too amazing not to share. Of course, all these models and experiments are brand new and the world needs independent verification and we want to make sure the effects will be safe long term. But you would have to already be dead not to get excited about the prospect of the kinds that we are talking about here. 

The details

Cells isolated from older people or animals have different patterns of chemicals along their DNA — called epigenetic markers — compared to younger people or animals. Scientists know that adding a mixture of four reprogramming molecules — Oct4, Sox2, Klf4 and cMyc, also known as “Yamanaka factors” — to cells can reset these epigenetic marks to their original patterns. This approach is how researchers can dial back adult cells, developmentally speaking, into stem cells.

This part of the data is not new and has been verified going back to 2016. These Yamanaka factors have been given to mice at many ages and timescales since then to check effectiveness and safety. And amazingly there were no increased rates of cancers These same mice did have similarities to younger mice but, even in young mice, the Yamanaka factors can accelerate muscle regeneration furth. Like super mice!

Read more here: https://www.sciencedaily.com/releases/2022/03/220307113027.htm